Title

Association of plasma C‐reactive protein with ischaemic stroke: a Mendelian randomization study

Author Identifier

Wei Wang Orcid: https://orcid.org/0000-0002-1430-1360

Document Type

Journal Article

Publication Title

European journal of neurology

Publisher

Wiley

School

School of Medical and Health Sciences

RAS ID

30234

Grant Number

NHMRC Number : 1112767

Comments

Zhang, X., Wang, A., Zhang, J., Singh, M., Liu, D., Zuo, Y., ... & Wang, Y. (2019). Association of plasma C‐reactive protein with ischaemic stroke: a Mendelian randomization study. European journal of neurology. Advance online publication.

https://doi.org/10.1111/ene.14113

Abstract

Background and purpose

Elevated C‐reactive protein (CRP) is associated with an increased risk of ischaemic stroke (IS). However, the causality of this association is uncertain. The aim is to investigate whether genetically raised plasma CRP concentration levels are associated with IS on the basis of the Mendelian randomization method.

Methods

Based on the National Center for Biotechnology Information single nucleotide polymorphism (SNP) database, the Chinese online genetic database as well as previously published studies, four CRP‐associated SNP alleles (rs1130864, rs1205, rs876537 and rs3093059) with minor allele frequency ≥0.15 were selected and the concentration levels of CRP were measured in 378 first‐ever IS patients and 613 healthy controls.

Results

Three SNPs were chosen and used as instrumental variables. The adjusted odds ratios (ORs) [95% confidence interval (95% CI)] of IS per addition of the modelled allele were 1.07 (0.79–1.45) for rs876537, 0.99 (0.73–1.35) for rs1205 and 1.08 (0.71–1.65) for rs3093059. The OR (95% CI) of IS for plasma CRP ≥2.0 mg/l was 2.19 (1.06–4.53) compared with

Conclusions

This Mendelian randomization study provides no clear support that elevated CRP concentration is causally associated with the risk of IS.

DOI

10.1111/ene.14113

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