Abstract

A higher intake of food rich in flavonoids such as quercetin can reduce the risk of CVD. Enzymatically modified isoquercitrin (EMIQ®) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential CVD moderating effects in animal studies. The present study aimed to determine whether acute ingestion of EMIQ® improves endothelial function, blood pressure (BP) and cognitive function in human volunteers at risk of CVD. Twenty-five participants (twelve males and thirteen females) with at least one CVD risk factor completed this randomised, controlled, crossover study. In a random order, participants were given EMIQ® (2 mg aglycone equivalent)/kg body weight or placebo alongside a standard breakfast meal. Endothelial function, assessed by flow-mediated dilatation (FMD) of the brachial artery was measured before and 1·5 h after intervention. BP, arterial stiffness, cognitive function, BP during cognitive stress and measures of quercetin metabolites, oxidative stress and markers of nitric oxide (NO) production were assessed post-intervention. After adjustment for pre-treatment measurements and treatment order, EMIQ® treatment resulted in a significantly higher FMD response compared with the placebo (1·80 (95 % CI 0·23, 3·37) %; P = 0·025). Plasma concentrations of quercetin metabolites were significantly higher (P < 0·001) after EMIQ® treatment compared with the placebo. No changes in BP, arterial stiffness, cognitive function or biochemical parameters were observed. In this human intervention study, the acute administration of EMIQ® significantly increased circulating quercetin metabolites and improved endothelial function. Further clinical trials are required to assess whether health benefits are associated with long-term EMIQ® consumption.

RAS ID

29892

Document Type

Journal Article

Date of Publication

1-28-2020

Funding Information

National Health and Medical Research Council Senior Research Fellowship.

School

School of Medical and Health Sciences

Publisher

Cambridge University Press

Comments

This article has been published in a revised form in the British Journal of Nutrition https://doi.org/10.1017/S0007114519002137

Bondonno, N. P., Bondonno, C. P., Ward, N. C., Woodman, R. J., Hodgson, J. M., & Croft, K. D. (2020). Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease. British Journal of Nutrition, 123(2), 182-189.

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Link to publisher version (DOI)

10.1017/S0007114519002137