Document Type
Journal Article
Publisher
IOS Press
School
School of Medical and Health Sciences
RAS ID
31501
Funders
Edith Cowan University - Open Access Support Scheme 2020
Abstract
Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in Alzheimer’s disease (AD) brain. Recent studies have identified PRKAG2 and TIPRL genes that control nutrient kinase regulated autophagy, and here we determined if their expression is altered in postmortem AD brains. Gene and protein expression of TIPRL were unchanged. However, gene expression of PRKAG2 was increased 3-fold and its protein levels positively correlated with Aβ accumulation in the AD brain. In summary, our findings suggest that increased PRKAG2 is an important contributing factor to Aβ accumulation in the AD brain.
DOI
10.3233/JAD-190948
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Bharadwaj, P., & Martins, R. N. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease,74(2) 441 - 448.
https://doi.org/10.3233/JAD-190948