Author Identifier

Prashant Bharadwaj

ORCID: https://orcid.org/0000-0003-4361-9906

Ralph Martins

ORCID: https://orcid.org/0000-0002-4828-9363

Document Type

Journal Article

Publisher

IOS Press

School

School of Medical and Health Sciences

RAS ID

31501

Funders

Edith Cowan University - Open Access Support Scheme

Comments

Bharadwaj, P., & Martins, R. N. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease,74(2) 441 - 448. https://doi.org/10.3233/JAD-190948

Abstract

Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in Alzheimer’s disease (AD) brain. Recent studies have identified PRKAG2 and TIPRL genes that control nutrient kinase regulated autophagy, and here we determined if their expression is altered in postmortem AD brains. Gene and protein expression of TIPRL were unchanged. However, gene expression of PRKAG2 was increased 3-fold and its protein levels positively correlated with Aβ accumulation in the AD brain. In summary, our findings suggest that increased PRKAG2 is an important contributing factor to Aβ accumulation in the AD brain.

DOI

10.3233/JAD-190948

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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