Document Type

Journal Article

Publication Title

Stress: the International Journal on the Biology of Stress

Publisher

Taylor and Francis

School

School of Medical and Health Sciences

RAS ID

30058

Comments

This is an Accepted Manuscript of an article published by Taylor & Francis in Stress on 14 November 2019, available online: http://www.tandfonline.com/10.1080/10253890.2019.1687683.

Yang, C. X., Wang, Y., Lu, Q., Lian, Y. N., Anto, E. O., Zhang, Y., & Wang, W. (2020). Chronic stress influences nociceptive sensitivity of female rats in an estrous cycle-dependent manner. Stress, 23(4) 386 - 392. https://doi.org/10.1080/10253890.2019.1687683

Abstract

Exposure to chronic stress can influence nociception and further induce hyperalgesia. Whether stress modulation of pain in female animals occurs in an estrous cycle-specific manner is still unclear. We profiled the changes in nociception (thermal, mechanical, formalin-evoked acute and inflammatory pain) of female Sprague-Dawley rats after treatment with chronic unpredictable mild stress (CUMS) and investigated whether these changes occur in an estrous cycle-dependent manner. The results showed that CUMS female rats exhibited a lower mechanical withdrawal threshold in proestrus and estrus, a longer formalin-evoked licking time in metestrus and diestrus, but no changes in the latency time on the tail-flick test. The present study findings suggest that chronic stress induces mechanical and formalin-evoked acute hyperalgesia of female rats in an estrous cycle-dependent manner.

DOI

10.1080/10253890.2019.1687683

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