Abstract

Purpose: Chronic inflammation plays a role in the pathogenesis of age-related renal disease and the diet can moderate systemic inflammation. The primary objective of this study was to examine the associations between a dietary inflammatory index ( DII®) score and renal function, the trajectory of renal function decline, and renal disease-related hospitalizations and/or mortality over 10 years.

Methods: The study was conducted in 1422 Western Australian women without prevalent chronic kidney disease and aged ≥ 70 years. Baseline dietary data, obtained from a validated food frequency questionnaire, were used to calculate a DII score for each individual.

Results: In this cohort, the mean [range] DII score was 0.19 [− 6.14 to 6.39]. A higher DII score was associated with poorer renal function at baseline and a greater renal function decline over 10 years; after multivariable adjustments, a one unit higher DII score was associated with a 0.55 mL/min/1.73 m2 lower eGFR at baseline (p = 0.01) and a 0.06 mL/min/1.73 m2 greater annual decline in eGFR over 10 years (p = 0.05). Restricted cubic splines provide evidence of a non-linear association between baseline DII score and risk of a renal disease-related event. Compared to participants in the lowest quintile, those in the highest quintile of DII score were at a higher risk of experiencing a renal disease-related event (adjusted HR 2.06, 95% CI 0.97, 4.37).

Conclusion: Recommending an increased consumption of foods with a higher anti-inflammatory potential could form part of a multifaceted approach to reduce the risk of renal disease through diet and lifestyle changes.

Keywords

Dietary inflammatory index, Chronic kidney disease, Renal disease, Renal decline, Prospective cohort study

Document Type

Journal Article

Date of Publication

1-1-2020

Publication Title

European Journal of Nutrition

Publisher

Springer

School

School of Medical and Health Sciences

RAS ID

30872

Funding Information

The study was supported by Kidney Health Australia grant S07 10, Healthway Health Promotion Foundation of Western Australia, Sir Charles Gairdner Hospital Research Advisory Committee Grant and by project grants 254,627, 303169 and 572604 from the National Health and Medical Research Council of Australia. The salary of JRL is supported by a National Health and Medical Research Council of Australia Career Development Fellowship (ID: 1107474). NPB is funded by a National Health and Medical Research Council Early Career Fellowship (Grant number APP1159914), Australia. The salary of JMH is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship, Australia (Grant number APP1116937). WL is supported by the Raine/University of Western Australia clinical fellowship. NS and JRH were supported by the United States National Institute for Diabetes, Digestive and Kidney Diseases (grant no. R44DK103377).

Funding received from the National Health and Medical Research Council (NHMRC)

1107474

Administering Institution

Edith Cowan University

Comments

This is a post-peer-review, pre-copyedit version of an article published in the European Journal of Nutrition. The final authenticated version is available online at: https://doi.org/10.1007/s00394-019-02160-9

Bondonno, N. P., Blekkenhorst, L. C., Bird, A. L., Lewis, J. R., Hodgson, J. M., Shivappa, N., ... & Lim, W. H. (2020). Dietary inflammatory index and the aging kidney in older women: a 10-year prospective cohort study. European Journal of Nutrition, 59, 3201–3211.

First Page

3201

Content Type

Full object

Last Page

3211

Recommended Citation

Bondonno, N. P., Blekkenhorst, L. C., Bird, A. L., Lewis, J. R., Hodgson, J. M., Shivappa, N., ... & Lim, W. H. (2020). Dietary inflammatory index and the aging kidney in older women: A 10-year prospective cohort study. European Journal of Nutrition, 59, 3201–3211.https://doi.org/10.1007/s00394-019-02160-9

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Link to publisher version (DOI)

10.1007/s00394-019-02160-9

National Health and Medical Research Council (NHMRC) ROR ID:

011kf5r70

Edith Cowan University (ECU) ROR ID:

05jhnwe22