Document Type
Journal Article
Publication Title
Translational Vision Science and Technology
Publisher
The Association for Research in Vision and Ophthalmology (ARVO)
School
School of Medical and Health Sciences
RAS ID
31705
Abstract
Purpose: Potential links may exist between vitamin A intake and myopia via various pathways. In this study, we examined the association between dietary vitamin A intake during adolescence and myopia in early adulthood. Methods: We performed a prospective analysis utilizing data collected from participants of the Raine Study Gen2. Dietary vitamin A intake, determined via food frequency questionnaires completed at ages 14, 17, and 20 years, was compared with ophthalmic measurements collected at year 20. Low vitamin A levels were defined as <600 >µg/day. Regression models were used to adjust for ocular sun exposure level, educational level, and parental myopia as potential confounders. Results: A total of 642 subjects were analyzed. Although those with adequate vitamin A intakes were less likely to be myopic (P = 0.03), this association became insignificant when adjusted for potential confounding factors in logistic regression modeling (odds ratio, 0.59; 95% confidence interval, 0.98–2.52; P = 0.06). Conclusions: There were no significant associations between total vitamin A intakes during adolescence and year 20 refractive errors after adjustment for confounders. Replication of this finding and further investigations are essential to rule out the suggestion that sufficient vitamin A intake during adolescence is associated with lower risk of myopia in early adulthood. Translational Relevance: Our findings are not definitive that ingesting foods high in vitamin A during childhood and adolescence does not have a role for preventing myopia in early adulthood.
DOI
10.1167/tvst.9.6.29
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Ng, F. J., Mackey, D. A., O'Sullivan, T. A., Oddy, W. H., & Yazar, S. (2020). Is Dietary Vitamin A Associated with Myopia from Adolescence to Young Adulthood?. Translational Vision Science & Technology, 9(6), 29-29. https://doi.org/10.1167/tvst.9.6.29