Document Type
Journal Article
Publication Title
Journal of Integrative Neuroscience
ISSN
02196352
Volume
19
Issue
2
First Page
273
Last Page
283
PubMed ID
32706191
Publisher
Innovative Medical Research Press
School
School of Nursing and Midwifery
RAS ID
31943
Abstract
© 2020 Pang et al. Published by IMR press. Focal cerebral ischemia-reperfusion injury is closely related to hyperglycemia and gut microbiota imbalance, while gut microbiota contributes to the regulation of brain function through the gut-brain axis. Previous studies in patients with diabetes have found that 'yam gruel' is a classic medicated diet made from Dioscorea polystachya, increases the content of Bifidobacterium, regulates oxidative stress, and reduces fasting blood glucose levels. The research reported here investigated the effects of 'yam gruel' on the cognitive function of streptozotocin-induced diabetic rats with focal cerebral ischemia-reperfusion injury and explored the mechanism underlying the role of the gut-brain axis in this process. 'Yam gruel' was shown to improve cognitive function as indicated by increased relative content of probiotic bacteria, and short-chain fatty acids in the intestinal tract and cerebral cortex reduced oxidative stress and inflammatory response and promotion of the expression of neurotransmitters and brain-derived neurotrophic factor. Thus, it is concluded that 'yam gruel' has a protective effect on cognitive function via a mechanism related to the gut-brain axis.
DOI
10.31083/j.jin.2020.02.69
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Pang, S. Q., Luo, Z. T., Wang, C. C., Hong, X. P., Zhou, J., Chen, F., ... & Zhang, J. H. (2020). Effects of Dioscorea polystachya'yam gruel'on the cognitive function of diabetic rats with focal cerebral ischemia-reperfusion injury via the gut-brain axis. Journal of Integrative Neuroscience, 19(2), 273-283. https://doi.org/10.31083/j.jin.2020.02.69