Voluntary exercise in mesothelioma: Effects on tumour growth and treatment response in a murine model

Authors

Scott A. Fisher
Carolyn J. Peddle-McIntyre, Edith Cowan UniversityFollow
Kimberley Burton
Robert U. Newton, Edith Cowan UniversityFollow
Elly Marcq
Richard A. Lake
Anna K. Nowak

Document Type

Journal Article

Publication Title

BMC Research Notes

Volume

13

Issue

1

First Page

435

PubMed ID

32933580

Publisher

Springer Nature

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

RAS ID

32252

Funders

National Health and Medical Research Council

Grant Number

NHMRC Number : 1107043

Grant Link

http://purl.org/au-research/grants/nhmrc/1107043

Comments

Fisher, S. A., Peddle-McIntyre, C. J., Burton, K., Newton, R. U., Marcq, E., Lake, R. A., & Nowak, A. K. (2020). Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model. BMC research notes, 13(1), Article 435. https://doi.org/10.1186/s13104-020-05284-y

Abstract

OBJECTIVE: There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen-induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced MexTAg model of mesothelioma. RESULTS: Asbestos exposed MexTAg mice were given continuous or delayed access to VE and ARD assessed over time. We found that the addition of VE did not affect ARD development in asbestos exposed MexTAg mice. However, non-asbestos exposed, aged matched control mice participated in significantly more VE behaviours, suggesting subclinical development of ARD after asbestos exposure had a greater impact on VE participation than age alone. These data highlight the importance of model choice and the potential limitation that some pre-clinical studies may not accurately represent the clinical paradigm, particularly in the context of prevention studies.

DOI

10.1186/s13104-020-05284-y

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.