Innovative diagnostic tools for early detection of Alzheimer's disease

Document Type

Journal Article

Publisher

Elsevier

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

18822

Comments

Laske, C., Sohrabi, H. R., Frost, S., Lopez-de-Ipina, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S., Mueller, S., Linnemann, C., Bridenbaugh, S., Kanagasingam, Y., Martins, R. N., & O'Bryant, S. (2015). Innovative diagnostic tools for early detection of Alzheimer's disease. Alzheimer's and Dementia, 11(5), 561-578. Available here

Abstract

Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost-effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests.

DOI

10.1016/j.jalz.2014.06.004

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