Abstract
© 2020 Xinjun Lin et al., published by De Gruyter 2020. There is increasing evidence of the linkage between type 2 diabetes mellitus (T2DM) and gut microbiota. Based on our previous studies, we investigated the hypoglycemic mechanisms of yam gruel to provide a scientific basis for its popularization and application. Wistar rats were randomly divided into control and T2DM model groups. Rats in the model group were stimulated by a high-sugar/high-fat diet combined with an intraperitoneal injection of streptozotocin to induce T2DM. The T2DM rats were further subdivided randomly into three groups: (1) DM, (2) DM + yam gruel, and (3) DM + metformin. After 4 weeks of intervention, the changes in gut microbiota, short-chain fatty acids (SCFAs) (acetic acid, propionic acid, and butyric acid), the expression of G protein-coupled receptor 43 (GPR43), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and fasted blood glucose (FBG) levels were observed. Yam gruel intervention elevated the abundance of probiotic bacteria and increased the expression of SCFAs, GPR43 receptor, GLP-1, and PYY. It also reduced FBG levels. We conclude that yam gruel can lower FBG by promoting the growth of probiotic bacteria, increasing the content of SCFAs, and enhancing the expression of GPR43 receptor to increase the content of GLP-1 and PYY in serum.
Document Type
Journal Article
Date of Publication
2020
Volume
15
Issue
1
Publication Title
Open Life Sciences
Publisher
Walter de Gruyter
School
School of Nursing and Midwifery
RAS ID
32379
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
First Page
763
Last Page
773
Comments
Lin, X., Luo, Z., Pang, S., Wang, C. C., Ge, L., Dai, Y., ... Zhang, J. (2020). The effects of yam gruel on lowering fasted blood glucose in T2DM rats. Open Life Sciences, 15(1), 763-773. https://doi.org/10.1515/biol-2020-0096