Document Type
Letter to the Editor
Publication Title
American Journal of Respiratory and Critical Care Medicine
Volume
202
Issue
12
First Page
1743
Last Page
1744
PubMed ID
32970450
Publisher
American Thoracic Society
School
School of Medical and Health Sciences
Abstract
We thank Dr. Lipworth and colleagues for their interest in our work published recently in the Journal (1). They rightly point out that the biology of asthma attacks is more complex than blood eosinophils alone and that corticosteroids have a wide range of other potentially relevant antiinflammatory effects. However, local treatment with inhaled corticosteroids (ICS) is usually the mainstay of patients with frequent eosinophilic exacerbations, and therefore in the great majority of patients, the key question is what oral corticosteroids (OCS) add to ICS in an acute attack (2) and whether this effect is seen with benralizumab. We suggest that depletion of circulating eosinophils is the only effect OCS are likely to have that are not shared with ICS (3).
DOI
10.1164/rccm.202008-3106LE
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Comments
Moran, A. M., Ramakrishnan, S., Borg, C. A., Connolly, C. M., Couillard, S., Mwasuku, C. M., … Lehtimӓki, L. (2020). Reply to Lipworth et al.: Don't forget about facilitatory effects of corticosteroids on β2-adrenoceptors in acute asthma. American Journal of Respiratory and Critical Care Medicine, 202(12), 1743-1744. https://doi.org/10.1164/rccm.202008-3106LE