Targeting mitophagy in Alzheimer's disease
Abstract
© 2020 - IOS Press and the authors. All rights reserved. Mitochondria perform many essential cellular functions including energy production, calcium homeostasis, transduction of metabolic and stress signals, and mediating cell survival and death. Maintaining viable populations of mitochondria is therefore critical for normal cell function. The selective disposal of damaged mitochondria, by a pathway known as mitophagy, plays a key role in preserving mitochondrial integrity and quality. Mitophagy reduces the formation of reactive oxygen species and is considered as a protective cellular process. Mitochondrial dysfunction and deficits of mitophagy have important roles in aging and especially in neurodegenerative disorders such as Alzheimer's disease (AD). Targeting mitophagy pathways has been suggested to have potential therapeutic effects against AD. In this review, we aim to briefly discuss the emerging concepts on mitophagy, molecular regulation of the mitophagy process, current mitophagy detection methods, and mitophagy dysfunction in AD. Finally, we will also briefly examine the stimulation of mitophagy as an approach for attenuating neurodegeneration in AD.
Document Type
Journal Article
Date of Publication
2020
Volume
78
Issue
4
PubMed ID
33285629
Publication Title
Journal of Alzheimer's Disease
Publisher
IOS Press
School
School of Medical and Health Sciences
RAS ID
35385
Copyright
subscription content
First Page
1273
Last Page
1297
Comments
Jayatunga, D. P. W., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G. J., & Martins, R. N. (2020). Targeting mitophagy in Alzheimer’s disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258