Abstract

Background:

Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. Materials and

Methods:

Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed.

Results:

Following the HK diet, ucOC and ucOC/tOC were suppressed more (p < 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (p > 0.05).

Discussion/Conclusion:

Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.

RAS ID

32185

Document Type

Journal Article

Date of Publication

11-24-2020

Volume

76

Issue

5

Funding Information

National Health and Medical Research Council

PubMed ID

33232964

School

School of Medical and Health Sciences

Grant Number

NHMRC Numbers : 1084922, 1116973, 1172987

Publisher

Karger Publishers

Comments

This is the Accepted Manuscript version of an article published by S. Karger AG in Annals of Nutrition and Metabolism/2020/volume 76/issue 5/pages 361-367], DOI 10.1159/000511660 and available on https://doi.org/10.1159/000511660

Tacey, A., Sim, M., Smith, C., Woessner, M. N., Byrnes, E., Lewis, J. R., ... Levinger, I. (2020). Association between circulating osteocalcin and cardiometabolic risk factors following a 4-week leafy green vitamin K-rich diet. Annals of Nutrition and Metabolism, 76(5), 361-367. https://doi.org/10.1159/000511660

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Link to publisher version (DOI)

10.1159/000511660