Abstract
Background: Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors.
Materials and Methods: Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed.
Results: Following the HK diet, ucOC and ucOC/tOC were suppressed more (p < 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (p > 0.05).
Discussion/Conclusion: Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.
Keywords
Arterial stiffness, Blood glucose, Blood lipids, Carboxylated osteocalcin, Undercarboxylated osteocalcin, Vitamin K
Document Type
Journal Article
Date of Publication
11-24-2020
Volume
76
Issue
5
PubMed ID
33232964
Publication Title
Annals of Nutrition and Metabolism
Publisher
Karger Publishers
School
School of Medical and Health Sciences
RAS ID
32185
Funding received from the National Health and Medical Research Council (NHMRC)
1084922, 1116973, 1172987
Administering Institution
Edith Cowan University
First Page
361
Content Type
Full object
Last Page
367
Recommended Citation
Tacey, A., Sim, M., Smith, C., Woessner, M. N., Byrnes, E., Lewis, J. R., & Levinger, I. (2020). Association between circulating osteocalcin and cardiometabolic risk factors following a 4-week leafy green vitamin K-rich diet. Annals of Nutrition and Metabolism, 76(5), 361-367. https://doi.org/10.1159/000511660
Comments
This is the Accepted Manuscript version of an article published by S. Karger AG in Annals of Nutrition and Metabolism/2020/volume 76/issue 5/pages 361-367], DOI 10.1159/000511660 and available on https://doi.org/10.1159/000511660
Tacey, A., Sim, M., Smith, C., Woessner, M. N., Byrnes, E., Lewis, J. R., ... Levinger, I. (2020). Association between circulating osteocalcin and cardiometabolic risk factors following a 4-week leafy green vitamin K-rich diet. Annals of Nutrition and Metabolism, 76(5), 361-367. https://doi.org/10.1159/000511660