Author Identifier

Marc Sim

https://orcid.org/0000-0001-5166-0605

Jonathan M. Hodgson

https://orcid.org/0000-0001-6184-7764

Document Type

Journal Article

Publication Title

Annals of Nutrition and Metabolism

Volume

76

Issue

5

First Page

361

Last Page

367

PubMed ID

33232964

Publisher

Karger Publishers

School

School of Medical and Health Sciences

RAS ID

32185

Funders

National Health and Medical Research Council

Grant Number

NHMRC Numbers : 1084922, 1116973, 1172987

Comments

This is the Accepted Manuscript version of an article published by S. Karger AG in Annals of Nutrition and Metabolism/2020/volume 76/issue 5/pages 361-367], DOI 10.1159/000511660 and available on https://doi.org/10.1159/000511660

Tacey, A., Sim, M., Smith, C., Woessner, M. N., Byrnes, E., Lewis, J. R., ... Levinger, I. (2020). Association between circulating osteocalcin and cardiometabolic risk factors following a 4-week leafy green vitamin K-rich diet. Annals of Nutrition and Metabolism, 76(5), 361-367. https://doi.org/10.1159/000511660

Abstract

Background:

Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. Materials and

Methods:

Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed.

Results:

Following the HK diet, ucOC and ucOC/tOC were suppressed more (p < 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (p > 0.05).

Discussion/Conclusion:

Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.

DOI

10.1159/000511660

Download

Share

 
COinS
 

Link to publisher version (DOI)

10.1159/000511660