Abstract
Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitus, hypertension, and ischemic stroke. Therefore, the aim is to investigate whether the effects of IgG N-glycan profiles on dementia exists in a Chinese Han population. A case–control study, including 81 patients with dementia, 81 age- and gender-matched controls with normal cognitive functioning (NC) and 108 non-matched controls with mild cognitive impairment (MCI) was performed. Plasma IgG N-glycans were separated by ultra-performance liquid chromatography. Fourteen glycan peaks reflecting decreased of sialylation and core fucosylation, and increased bisecting N-acetylglucosamine (GlcNAc) N-glycan structures were of statistically significant differences between dementia and NC groups after controlling for confounders (p < 0.05; q < 0.05). Similarly, the differences for these 14 initial glycans were statistically significant between AD and NC groups after adjusting for the effects of confounders (p < 0.05; q < 0.05). The area under the receiver operating curve (AUC) value of the model consisting of GP8, GP9, and GP14 was determined to distinguish dementia from NC group as 0.876 [95% confidence interval (CI): 0.815–0.923] and distinguish AD from NC group as 0.887 (95% CI: 0.819–0.936). Patients with dementia were of an elevated proinflammatory activity via the significant changes of IgG glycome. Therefore, IgG N-glycans might contribute to be potential novel biomarkers for the neurodegenerative process risk assessment of dementia.
RAS ID
32771
Document Type
Journal Article
Date of Publication
2021
Funding Information
National Key R&D Program of China
European Commission Horizon 2020
National Natural Science Foundation of China
China-Australian Collaborative Grant
School
School of Medical and Health Sciences
Grant Number
NHMRC Number : 1112767
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Publisher
Springer Nature
Recommended Citation
Zhang, X., Yuan, H., Lyu, J., Meng, X., Tian, Q., Li, Y., Zhang, J., Xu, X., Su, J., Hou, H., Li, D., Sun, B., Wang, W., & Wang, Y. (2021). Association of dementia with immunoglobulin G N-glycans in a Chinese Han population. DOI: https://doi.org/10.1038/s41514-021-00055-w
Comments
Zhang, X., Yuan, H., Lyu, J., Meng, X., Tian, Q., Li, Y., ... Wang, Y. (2021). Association of dementia with immunoglobulin GN-glycans in a Chinese Han population. NPJ Aging and Mechanisms of Disease, 7, article 3. https://doi.org/10.1038/s41514-021-00055-w