Pick me, pick me! Rationale for investigating persistent inward currents (PICs) and associated exercise effects in the ageing neuromuscular system

Abstract

The loss of neuromuscular function with ageing has been extensively documented. Physiologically, muscular fibre atrophy, loss and denervation along with associated motor unit remodelling occur with, and continue into, ageing. Although motor unit remodelling serves to reinnervate and preserve local muscle fibres and thus function, overall reductions in muscle strength and power are linked to greater risk of falling, associated co‐morbidities and all‐cause mortality amongst elderly individuals.

RAS ID

36171

Document Type

Other

Date of Publication

2021

PubMed ID

33491208

School

School of Medical and Health Sciences

Copyright

free_to _read

Publisher

Wiley

Comments

Latella, C. (2021). Pick me, Pick me! Rationale for investigating persistent inward currents (PICs) and associated exercise effects in the ageing neuromuscular system. The Journal of Physiology, 599(7), 1957-1959. https://doi.org/10.1113/JP281324

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Link to publisher version (DOI)

10.1113/JP281324