Date of Award
2018
Document Type
Thesis - ECU Access Only
Publisher
Edith Cowan University
Degree Name
Doctor of Philosophy
School
School of Medical and Health Sciences
First Supervisor
Professor Ralph Martins
Second Supervisor
Dr Prashant R. Bharadwaj
Third Supervisor
Dr Stephanie Rainey-Smith
Fourth Supervisor
Dr Giuseppe Verdile
Abstract
Alzheimer’s disease (AD) is a progressive degenerative disease of the brain and is associated with a number of cardiovascular disease risk factors. Dyslipidemia is a systemic metabolic change that occurs early in AD and recent studies have suggested using medicinal plant extracts as an effective treatment to slow the cognitive decline in AD. The main aim of this study is to investigate the clinical benefits of Amla, a bioactive Indian gooseberry, and to explore its potential cellular mechanisms that may underlie its effects. The findings presented in this thesis provide significant insight into our understanding of the lipid changes in blood and how they relate to AD pathogenesis and also into the possible molecular mechanisms underlying Amla’s beneficial effects.
Recommended Citation
Teimouri, E. (2018). Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing Alzheimer’s risk. Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/2108