Document Type

Journal Article

Publication Title

Molecular Nutrition and Food Research

Volume

68

Issue

10

PubMed ID

38704751

Publisher

Wiley

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

RAS ID

71195

Funders

National Heart Foundation of Australia

Grant Number

102817

Comments

Hill, C. R., Shafaei, A., Matthews, V. B., Ward, N. C., Croft, K. D., Lewis, J. R., ... & Blekkenhorst, L. C. (2024). S‐Methyl cysteine sulfoxide does not ameliorate weight gain or hyperlipidemia in mice fed a high‐fat diet. Molecular Nutrition & Food Research, 2400034. https://doi.org/10.1002/mnfr.202400034

Abstract

Scope: Higher intake of cruciferous and allium vegetables is associated with lower cardiometabolic risk. Little research has investigated the cardiometabolic effects of S-methyl cysteine sulfoxide (SMCSO), found abundant in these vegetables. This study hypothesizes that SMCSO will blunt development of metabolic syndrome features in mice fed high-fat feed. Methods and results: Fifty C57BL/6 male mice are randomly assigned to standard-chow, high-fat, or high-fat supplemented with low-SMCSO (43 mg kg−1 body weight [BW] day−1), medium-SMCSO (153 mg kg−1 BW day−1), or high-SMCSO (256 mg kg−1 BW day−1) for 12-weeks. High-fat with SMCSO did not prevent diet-induced obesity, glucose intolerance, or hypercholesterolemia. Mice fed high-fat with SMCSO has higher hepatic lipids than mice fed standard-chow or high-fat alone. Urinary SMCSO increases at 6- and 12-weeks in the low-SMCSO group, before reducing 46% and 28% in the medium- and high-SMCSO groups, respectively, at 12-weeks, suggesting possible tissue saturation. Interestingly, two SMCSO-fed groups consume significantly more feed, without significant weight gain. Due to limitations in measuring consumed feed, caution should be taken interpreting these results. Conclusion: SMCSO (43–256 mg kg−1 BW day−1) does not ameliorate metabolic syndrome features in high-fat fed mice. Substantial knowledge gaps remain. Further studies should administer SMCSO separately (i.e., gavage), with metabolic studies exploring tissue levels to better understand its physiological action.

DOI

10.1002/mnfr.202400034

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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