S-Methyl cysteine sulfoxide From brassica and allium vegetables and its effects upon cardiometabolic health in high-fat fed mice
Author Identifier
Caroline Hill: https://orcid.org/0000-0001-9291-3648
Lois Balmer: https://orcid.org/0000-0001-5618-0555
Jonathan Hodgson: https://orcid.org/0000-0001-6184-7764
Armaghan Shafaei: https://orcid.org/0000-0002-5763-531X
Document Type
Journal Article
Publication Title
Heart, Lung and Circulation
Publisher
Elsevier
School
Nutrition and Health Innovation Research Institute / Centre for Precision Health / School of Medical and Health Sciences / School of Science
Abstract
Background: S-methyl cysteine sulfoxide (SMCSO) is a sulfur-based compound abundant in cruciferous (e.g., broc- coli, kale) and allium (e.g., onion, garlic) vegetables [1]. Higher intake of these vegetables is associated with car- diometabolic risk reduction [2]. Whether SMCSO mediates some of these benefits is unknown. Methods: We investigated whether SMCSO blunted the negative cardiometabolic effects of a high-fat diet (HFD) in mice. Fifty-four male C57BL/6 mice were randomised into five groups: normal chow, HFD, or HFD with low, medium, or high SMCSO (60, 170, or 350 mg/kg of body weight) administered via oral gavage daily for 12 weeks. Results: Mice fed the HFD experienced greater weight gain, glucose intolerance, and elevated lipids [total-, low- density-lipoprotein- (LDL-C), and high-density-lipoprotein- (HDL-C) cholesterols], compared to mice consuming normal chow (all p,0.05). Adding medium or high-SMCSO to the HFD blunted the elevated HDL-C (-11% and -12%; p#0.05), whilst high-SMCSO reduced triglycerides (-16%; p,0.05) (Figure 1). There were insignificant reductions in total cholesterol, LDL-C, and glucose tolerance in the SMCSO- administered groups, compared to those consuming HFD alone. SMCSO did not prevent weight gain from the HFD, even after adjusting for energy intake. Conclusions: SMCSO elicited favourable lipid changes in the HFD fed mice. Whether SMCSO imparts positive lipid outcomes in humans remains to be explored.
DOI
10.1016/j.hlc.2024.06.784
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Comments
Hill, C., Balmer, L., Abbiss, H., Hodgson, J., Lewis, J., Shafaei, A., & Blekkenhorst, L. (2024). S-Methyl cysteine sulfoxide from brassica and allium vegetables and its efects upon cardiometabolic health in high-fat fed mice. Heart, Lung and Circulation, 33, S484-S485. https://doi.org/10.1016/j.hlc.2024.06.784