Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy: A longitudinal cohort study
Abstract
Aims
To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort.
Methods
We included 4237 individuals with type 2 diabetes during 2013–2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin–Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95 % confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression.
Results
The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098–1.329) and 1.216 (95 % CI: 1.102 – 1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest.
Conclusion
Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.
Document Type
Journal Article
Date of Publication
9-1-2022
Volume
191
PubMed ID
36099974
Publication Title
Diabetes Research and Clinical Practice
Publisher
Elsevier
School
Centre for Precision Health
RAS ID
46971
Copyright
subscription content
Comments
Wu, Z., Yu, S., Zhu, Q., Li, Z., Zhang, H., Kang, X., ... & Guo, X. (2022). Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy: A longitudinal cohort study. Diabetes Research and Clinical Practice, 191, Article 110079.
https://doi.org/10.1016/j.diabres.2022.110079