Combined evaluation of arterial stiffness, glycemic control and hypertension for macrovascular complications in type 2 diabetes

Authors

Zhiyuan Wu, Edith Cowan UniversityFollow
Siqi Yu
Haiping Zhang
Zheng Guo, Edith Cowan UniversityFollow
Yulu Zheng, Edith Cowan UniversityFollow
Zongkai Xu
Zhiwei Li
Xiangtong Liu
Xia Li
Shuo Chen
Jingbo Zhang
Lixin Tao
Xiuhua Guo

Document Type

Journal Article

Publication Title

Cardiovascular Diabetology

Volume

21

Issue

1

PubMed ID

36443820

Publisher

Springer

School

Centre for Precision Health / School of Medical and Health Sciences

RAS ID

54050

Funders

National Natural Science Foundation of China (Numbers: 81872708 and 82073668 to LX. Tao)

Comments

Wu, Z., Yu, S., Zhang, H., Guo, Z., Zheng, Y., Xu, Z., ... & Guo, X. (2022). Combined evaluation of arterial stiffness, glycemic control and hypertension for macrovascular complications in type 2 diabetes. Cardiovascular Diabetology, 21, 262. https://doi.org/10.1186/s12933-022-01696-1

Abstract

Background: Arterial stiffness, glycemic control and blood pressure are risk factors of macrovascular complications in type 2 diabetes. This study aimed to investigate the combined association of arterial stiffness, glycemic control and hypertension status with the occurrence of diabetic macrovascular complication. Methods: A total of 1870 patients of diabetes were enrolled from Beijing Health Management Cohort between 2008 and 2018 as baseline, and then followed for macrovascular complication onset. We proposed a composite risk score (0 – 4) by arterial stiffness severity, pool glycemic control and hypertension status. Cox model was used to estimate the hazard ratio (HR) and 95 % confidence interval (CI). Results: The mean age (SD) of this population was 59.90 (12.29) years. During a median follow-up of 4.0 years, 359 (19.2 %) patients developed macrovascular complication. Compared to the normal arterial stiffness and good glycemic control group, patients with severe arterial stiffness and pool glycemic control had the highest risk of macrovascular complications (HR: 2.73; 95 % CI: 1.42 – 5.25). Similarly, those of severe arterial stiffness and hypertension had the highest risk (HR: 2.69; 95 % CI: 1.61 – 4.50). Patients of the composite score > 2 had a significantly increased risk of macrovascular complication. Conclusion: This study suggested the clinical importance of combined evaluation of arterial stiffness, glycemic control and hypertension status for the risk stratification and management of macrovascular complication of type 2 diabetes.

DOI

10.1186/s12933-022-01696-1

Creative Commons License

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