Title

Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy: A longitudinal cohort study

Document Type

Journal Article

Publication Title

Diabetes Research and Clinical Practice

Volume

191

PubMed ID

36099974

Publisher

Elsevier

School

Centre for Precision Health

RAS ID

46971

Comments

Wu, Z., Yu, S., Zhu, Q., Li, Z., Zhang, H., Kang, X., ... & Guo, X. (2022). Association of baseline and cumulative remnant cholesterol with incidence of diabetic nephropathy: A longitudinal cohort study. Diabetes Research and Clinical Practice, 191, Article 110079.

https://doi.org/10.1016/j.diabres.2022.110079

Abstract

Aims

To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort.

Methods

We included 4237 individuals with type 2 diabetes during 2013–2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin–Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95 % confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression.

Results

The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098–1.329) and 1.216 (95 % CI: 1.102 – 1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest.

Conclusion

Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.

DOI

10.1016/j.diabres.2022.110079

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