Document Type
Journal Article
Publication Title
Respirology
Volume
28
Issue
6
First Page
561
Last Page
570
PubMed ID
36642702
Publisher
Wiley
School
School of Medical and Health Sciences / Exercise Medicine Research Institute
RAS ID
54253
Funders
Cancer Council Western Australia / Sir Charles Gairdner Research Advisory Group
Abstract
Background and Objective: Device-assessed activity behaviours are a novel measure for comparing intervention outcomes in patients with malignant pleural effusion (MPE). Australasian Malignant PLeural Effusion (AMPLE)-2 was a multi-centre clinical trial where participants with MPE treated with an indwelling pleural catheter were randomized to daily (DD) or symptom-guided (SGD) drainage for 60-days. Our aim was to describe activity behaviour patterns in MPE patients, explore the impact of drainage regimen on activity behaviours and examine associations between activity behaviours and quality of life (QoL). Methods: Following randomization to DD or SGD, participants enrolled at the lead site (Perth) completed accelerometry assessment. This was repeated monthly for 5-months. Activity behaviour outcomes were calculated as percent of daily waking-wear time and compared between groups (Mann–Whitney U test; Median [IQR]). Correlations between activity behaviour outcomes and QoL were examined. Results: Forty-one (91%) participants provided ≥ 1 valid accelerometry assessment (DDn = 20, SGD n = 21). Participants spent a large proportion of waking hours sedentary (72%–74% across timepoints), and very little time in moderate-to-vigorous physical activity ( < 1% across timepoints). Compared to SGD group, DD group had a more favourable sedentary-to-light ratio in the week following randomization (2.4 [2.0–3.4] vs. 3.2 [2.4–6.1]; p = 0.047) and at 60-days (2.0 [1.9–2.9] vs. 2.9 [2.8–6.0]; p = 0.016). Sedentary-to-light ratio was correlated with multiple QoL domains at multiple timepoints. Conclusion: Patients with MPE are largely sedentary. Preliminary results suggest that even modest differences in activity behaviours favouring the DD group could be meaningful for this clinical population. Accelerometry reflects QoL and is a useful outcome measure in MPE populations.
DOI
10.1111/resp.14451
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Peddle‐McIntyre, C. J., Muruganandan, S., McVeigh, J., Fitzgerald, D. B., Straker, L., Newton, R. U., ... & Lee, Y. C. G. (2023). Device assessed activity behaviours in patients with indwelling pleural catheter: A sub‐study of the Australasian Malignant PLeural Effusion (AMPLE)‐2 randomized trial. Respirology, 28(6), 561-570. https://doi.org/10.1111/resp.14451