Document Type
Journal Article
Publication Title
Neurobiology of Aging
Publisher
Elsevier
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
61967
Funders
https://doi.org/10.1016/j.neurobiolaging.2023.09.002
Abstract
Dysfunction of the cholinergic basal forebrain (BF) system and amyloid- (A ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed A -PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and A status (A −, A +). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high A levels correlated with faster volume loss in the BF and hippocampus, and the effect of A varied within BF subregions. Compared to CU A + individuals, A -related loss among CI A + adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD. © 2023 The Author(s)
DOI
10.1016/j.neurobiolaging.2023.09.002
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Xia, Y., Maruff, P., Doré, V., Bourgeat, P., Laws, S. M., Fowler, C., . . . Fripp, J. (2023). Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer’s disease. Neurobiology of Aging, 132, 120-130. https://doi.org/10.1016/j.neurobiolaging.2023.09.002