Document Type
Journal Article
Publication Title
International Journal of Clinical and Health Psychology
Volume
24
Issue
1
Publisher
Elsevier
School
Centre for Precision Health / School of Medical and Health Sciences
RAS ID
62632
Funders
National Health and Medical Research Council
Grant Number
NHMRC Number : GNT1097105
Grant Link
http://purl.org/au-research/grants/nhmrc/GNT1097105
Abstract
Background/Objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms. Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE 4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms. Results: The exercise intervention did not influence mental health symptoms. The BDNF Val66Met polymorphism did not moderate intervention effects on mental health symptoms. APOE 4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that APOE 4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months. Conclusions: APOE 4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that APOE 4 carriers show a greater decline in stress as a result of exercise relative to non-APOE 4 carriers.
DOI
10.1016/j.ijchp.2024.100443
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Gujral, S., Burns, M., Erickson, K. I., Rofey, D., Peiffer, J. J., Laws, S. M., & Brown, B. (2024). Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators. International Journal of Clinical and Health Psychology, 24(1), article 100443. https://doi.org/10.1016/j.ijchp.2024.100443