Abstract
Background: The association between visceral adiposity index (VAI) and diabetic complications has been reported in cross-sectional studies, while the effect of VAI on complication development remains unclear. This study aims to evaluate the longitudinal association of VAI and Chinese VAI (CVAI) with the incidence of diabetic nephropathy and retinopathy using a Chinese cohort. Methods: A total of 8 948 participants with type 2 diabetes from Beijing Health Management Cohort were enrolled during 2013–2014, and followed until December 31, 2019. Nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate; retinopathy was diagnosed using fundus photograph. Results: The mean (SD) age was 53.35 (14.66) years, and 6 154 (68.8%) were men. During a median follow-up of 4.82 years, 467 participants developed nephropathy and 90 participants developed retinopathy. One-SD increase in VAI and CVAI levels were significantly associated with an increased risk of nephropathy, and the adjusted hazard ratios (HR) were 1.127 (95% CI 1.050–1.210) and 1.165 (95% CI 1.003–1.353), respectively. On contrary, VAI and CVAI level were not associated with retinopathy after adjusting confounding factors. Conclusion: VAI and CVAI are independently associated with the development of nephropathy, but not retinopathy in Chinese adults with diabetes.
Document Type
Journal Article
Date of Publication
12-1-2022
Volume
21
Issue
1
PubMed ID
35209907
Publication Title
Cardiovascular Diabetology
Publisher
Springer
School
Centre for Precision Health
RAS ID
43591
Funders
National Natural Science Foundation of China (81872708, 82073668)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Wu, Z., Yu, S., Kang, X., Liu, Y., Xu, Z., Li, Z., ... & Guo, X. (2022). Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population. Cardiovascular diabetology, 21(1), 1-9. https://doi.org/10.1186/s12933-022-01464-1