Document Type
Journal Article
Publication Title
Cancer Reports
Volume
7
Issue
8
PubMed ID
39118235
Publisher
Wiley
School
Exercise Medicine Research Institute / School of Medical and Health Sciences
Funders
Edith Cowan University / Australian Government / Western Australian Cancer Council
Abstract
Objectives: In ovarian and other cancers, low muscle mass and density are associated with poorer clinical outcomes. However, screening for cancer-related sarcopenia (typically defined as low muscle mass) is not routinely conducted. The European Working Group on Sarcopenia in Older People (EWGSOP) recommends an algorithm for sarcopenia screening and diagnosis in clinical settings, with sarcopenia based on muscle strength and mass, and severity on physical performance. We explored the application of the EWGSOP2 algorithm to assess sarcopenia in six ovarian cancer patients receiving neoadjuvant chemotherapy. Methods: We assessed sarcopenia risk with the SARC-F screening questionnaire (at risk ≥4 points), muscle strength with a handgrip strength test (cut point <16 kg) and five times sit-to-stand test (cut point >15 s), muscle mass by skeletal muscle index (SMI in cm2/m2 from a single computed tomography [CT] image; cut point <38.5 cm2/m2), and physical performance with a 4-m gait speed test (cut point ≤0.8 m/s). Results: Of six participants, none were identified as “at risk” for sarcopenia based on SARC-F scores. Two participants were severely sarcopenic based on EWGSOP2 criteria (had low muscle strength, mass, and physical performance), and five participants were sarcopenic based on muscle mass only. Discussion: Ovarian cancer patients with low muscle mass during neoadjuvant chemotherapy may not be identified as sarcopenic based on the EWGSOP2 diagnostic algorithm. While lacking a universally accepted definition for cancer-related sarcopenia and cancer-specific recommendations for the screening, diagnosis, and treatment of sarcopenia, ovarian cancer clinicians should focus on the diagnosis and treatment of low muscle mass and density.
DOI
10.1002/cnr2.2155
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Schofield, C., Taaffe, D. R., Newton, R. U., Galvão, D. A., Cohen, P. A., Kim, J. S., ... & Peddle‐McIntyre, C. (2024). Assessing sarcopenia in advanced‐stage ovarian cancer patients undergoing neoadjuvant chemotherapy: A case series. Cancer Reports, 7(8), e2155. https://doi.org/10.1002/cnr2.2155