Associations between maternal preconception and pregnancy adiposity and neuropsychiatric and behavioral outcomes in the offspring: A systematic review and meta-analysis

Authors

Bereket Duko
Tesfaye S. Mengistu
David Stacey
Lisa J. Moran
Gizachew Tessema
Gavin Pereira
Asres Bedaso
Amanuel Tesfay Gebremedhin, Edith Cownan UniversityFollow
Rosa Alati
Oyekoya T. Ayonrinde
Beben Benyamin
S. Hong Lee
Elina Hyppönen

Document Type

Journal Article

Publication Title

Psychiatry Research

Volume

342

Publisher

Elsevier

School

School of Nursing and Midwifery

RAS ID

72576

Funders

Monash University / CRE HiPP

Comments

Duko, B., Mengistu, T. S., Stacey, D., Moran, L. J., Tessema, G., Pereira, G., ... & Hyppönen, E. (2024). Associations between maternal preconception and pregnancy adiposity and neuropsychiatric and behavioral outcomes in the offspring: A systematic review and meta-analysis. Psychiatry Research, 342. https://doi.org/10.1016/j.psychres.2024.116149

Abstract

Maternal adiposity (overweight or obesity) has been associated with adverse perinatal outcomes, although the potential risks of long-term neuropsychiatric and behavioral outcomes in the offspring remain unclear. Using the PRISMA guidelines, we searched PubMed, EMBASE, Scopus, and Web of Science to identify studies on maternal adiposity and offspring neuropsychiatric outcomes. Inverse variance-weighted random-effects meta-analyses were used to pool effect estimates with 95 % confidence intervals (95 % CIs) from adjusted odds ratios (OR) and hazard ratios (HR). Estimates were computed separately for preconception and pregnancy maternal overweight and obesity, with outcomes stratified by the type of neuropsychiatric outcome. In our meta-analyses of 42 epidemiological studies involving 3,680,937 mother-offspring pairs, we found increased risks of ADHD [OR=1.57, 95 % CI: 1.42-1.74], autism spectrum disorder [OR=1.42, 95 % CI: 1.22-1.65], conduct disorder [OR=1.16, 95 % CI: 1.00-1.35], Psychotic disorder [HR=1.61, 95 % CI: 1.41-1.83], externalizing behaviors [OR=1.30, 95 % CI: 1.07-1.56] and peer relationship problems [OR=1.25, 95 % CI: 1.04-1.27] in the offspring of preconception obese mothers. Similar increased risks were found in the offspring of preconception overweight mothers and those exposed to maternal adiposity during pregnancy. However, no association was found with offspring mood, anxiety, personality, eating, sleep disorders or prosocial problems. Preconception weight management may mitigate such adverse effects in the offspring.

DOI

10.1016/j.psychres.2024.116149

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