Author Identifier
Document Type
Journal Article
Publication Title
Journal of Inflammation Research
Volume
17
First Page
11347
Last Page
11356
Publisher
Dove Press
School
Centre for Precision Health / School of Medical and Health Sciences
RAS ID
77460
Funders
Faculty Development Grants from Hubei University of Medicine (2023QDJZR16) / Faculty Development Grants of Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine (XYY2024D02) / China Postdoctoral Science Foundation (2023M732772) / Young Elite Scientists Sponsorship Program by CAST (2023QNRC001)
Abstract
Objective: This study aimed to longitudinally investigate the association between circulating neutrophil count and the progression of arterial stiffness and to ascertain whether resting heart rate (RHR) mediates this association. Methods: The current study included 56,760 participants with brachial-ankle pulse wave velocity (baPWV) measurements from a real-life, prospective cohort in China. The associations of circulating neutrophil (exposure) with baseline baPWV, baPWV progression, and arterial stiffness (outcomes), as well as RHR (mediator) were assessed using multivariable linear and Cox regression models and mediation analysis. Results: After adjusting for cardiometabolic risk factors, for each 1-SD increase in neutrophil count, the corresponding increase was 13.5 cm/s (95% CI, 11.1 to 15.9 cm/s, P<0.001) for the baseline baPWV and 3.10 cm/s (95% CI, 1.51 to 4.69, P<0.001) for the annual change in baPWV. Over a median follow-up period of 4.08 (IQR: 2.37 to 6.21) years, there were 3,376 incident cases of arterial stiffness among the 23,263 participants. Each 1-SD increase in neutrophil count was associated with a 7% increase in the risk of developing arterial stiffness (HR: 1.07; 95% CI: 1.04 to 1.10, P<0.001) in the multivariable-adjusted model. In the mediation analyses, 20.0% (95% CI: 16.8% to 24.2%), 12.6% (95% CI: 8.16% to 26.4%), and 16.7% (95% CI: 9.94% to 51.0%) of the observed associations of neutrophil counts with baPWV at baseline, baPWV progression and developing arterial stiffness, respectively, were mediated by RHR. Conclusion: The present study underlines that circulating neutrophil count is significantly associated with arterial stiffness progression and that the RHR is, in part, a mediator of this association.
DOI
10.2147/JIR.S488928
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Wu, Z., Wu, D., Chen, S., Xu, S., Zhang, S., & Wu, S. (2024). Resting heart rate mediates the association between circulating neutrophil count and arterial stiffness progression: The Kailuan study. Journal of Inflammation Research, 17, 11347-11356. https://doi.org/10.2147/JIR.S488928